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KMID : 1035620170050050294
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Allergy Asthma & Respiratory Disease
2017 Volume.5 No. 5 p.294 ~ p.297
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A case of oral desensitization for hypersensitivity to exogenous progesterone
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Kim Young-Chan
Choi Kook-Hwan
Kang Dong-Yoon
Sohn Kyung-Hee
Cho Sang-Heon
Min Kyung-Up
Kang Hye-Ryun
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Abstract
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Hypersensitivity reaction to progesterone is a rare pathologic condition which consists of autoimmune response to endogenous progesterone, known as autoimmune progesterone dermatitis, and hypersensitivity reaction to exogenous progestogen. We report the case of a 31-year-old woman with a history of whole body urticaria during exogenous progesterone supplementation for in vitro fertilization (IVF). She was admitted to the hospital for the diagnosis and management of progestogen hypersensitivity. An intradermal test with progesterone revealed positivity to 5 mg/mL of progesterone. For her next IVF, progesterone desensitization was performed in a method combining oral and intramuscular progesterone administration. After successfully achieving a target dose of 100 mg per day, the route of progesterone administration was converted to intravaginal tablet (90 mg twice a day) without any hypersensitivity reactions.
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KEYWORD
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Progesterone, Drug hypersensitivity, Fertilization in vitro, Immunologic desensitization
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